Further, a marked increase in uncoupling protein 3 (Ucp3) and Krüppel-like factor 15 (Klf15) expression in the skeletal muscle (Figure 9) may promote lipid utilization and help mitigate lipid-induced insulin resistance in Ctrp10 KO female mice (Choi et al., 2007; Fan et al., 2021). This evidence concerns the gene UCP3 and Insulin resistance.