In addition, the upregulated hepatic expression of IL-22 receptor (Il22ra1) in Ctrp10 KO female mice (Figure 9) may confer protection against obesity-associated fatty liver, inflammation and fibrosis (Kong et al., 2012; Yang et al., 2010; Wang et al., 2014). Here, IL22RA1 is linked to obesity due to melanocortin 4 receptor deficiency.