LEP and Insulin resistance: In the case of adiponectin overexpression in leptin-deficient (ob/ob) male and female mice, a dramatic expansion of the subcutaneous fat pad is thought to promote lipid sequestration in adipose compartment, thus preventing ectopic lipid deposition in non-adipose tissues (e.g. liver, pancreas, muscle) that would otherwise induce insulin resistance (Kim et al., 2007).