On the other hand, the expression level of another architectural DNA and nucleosome‐binding protein member of the high mobility group protein (HMG) family, high‐mobility group box‐1 (HMGB1), was not positively associated with ISG15 in HCC patients from cBioPortal (Figure S1M, Supporting Information). Here, HMGB1 is linked to hepatocellular carcinoma.