ISG15 and hepatocellular carcinoma: HMGA1 was consistently upregulated in HCC samples (Figure S1H, Supporting Information, data from GEPIA); moreover, HMGA1 levels were further elevated in HCC tissues with steatosis compared with those from steatosis‐free HCC clinical samples (Figure S1I, Supporting Information; GEO GSE193084).[32] Correlation analysis from cBioPortal indicated a positive correlation between the levels of HMGA1 and ISG15 (Figure S1J, Supporting Information), and significantly lower overall survival rates were found in HCC patients with high HMGA1 levels (Figure S1K, Supporting Information, data from UALCAN).