HMGA1 and hepatocellular carcinoma: High mobility group A1 (HMGA1) is an essential nonhistone chromatin structural protein, participating in a myriad of cellular processes, including malignant transformation, embryogenesis and transcriptional regulation.[31] In HCC tumors from HFD‐fed mice (DEN+HFD), Hmga1 was upregulated at both mRNA and protein levels (Figure 2B,C,E).