Excessive lipid deposition often leads to pathology of organs, such as liver and kidney.[25, 26] To determine whether ISG15 is upregulated in other fat‐associated diseases, we studied ISG15 transcriptional levels in NAFLD (hepatic steatosis) and minimal change glomerulopathy (MCD) (GEO GSE130970 & GSE200828).[27] Significantly elevated ISG15 was found in hepatic steatosis and MCD compared with normal liver and kidney tissues (Figure S1C,D, Supporting Information). This evidence concerns the gene ISG15 and metabolic dysfunction-associated steatotic liver disease.