AKT1 and neoplasm: Elevated expression of cadherin‐11 can further promote the growth, migration, and invasion of Fb‐like synoviocytes in D‐TCGT.[45] Consistently, in our scRNA‐seq data, pathway analysis of MP3 tumor cells with core regulatory functions in D‐TGCT revealed activation of PI3K/Akt signaling (Figure 5B).