MYC and neoplasm: The further direct link between glycolysis and MYC was confirmed in vivo in inducible MYC-driven malignancies analyzed by hyperpolarized 13C pyruvate Magnetic Resonance Spectroscopic Imaging, in which an increase flux of pyruvate to lactate is seen in primary tumors compared to normal or pre-tumor nodules and which was also reversible upon MYC inhibition [15,16].