While driver gene mutations like APC (Adenomatous Polyposis Coli), TP53 (Tumor protein p53), and KRAS (Kirsten rat sarcoma viral oncogene homolog) have long been recognized as key players in the transition from adenoma to carcinoma in CRC [3], recent research suggests that microRNAs (miRNAs) may also have a critical role in this process [4]. The gene discussed is APC; the disease is colorectal carcinoma.