Second, the germinal center B-cell-like (GCB) DLBCL subtype displays a gene expression profile (GEP) related to a GC cell of origin, and is defined by a IGH::BCL2 fusion due to a translocation, t(14;18)(q32;q21), and mutations of genes important for GC development, GC dark zone and light zone transitions and microenvironmental interactions, such as EZH2, GNA13, MEF2B, KMT2D, TNFRSF14, B2M, and CREBBP [15]. This evidence concerns the gene BCL2 and diffuse large B-cell lymphoma.