Mice were respectively administered the vehicle (control), KMT5C inhibitor (A196), PD‐1 antibody (PD‐1 Ab), or a combination of A196 and PD‐1 antibody (combined), and the results revealed that KMT5C inhibitor A196 could reduce the tumor volume and weight compared with the control group, the combination therapy group displayed more effective in inhibiting tumor progression than A196 or PD‐1 Ab alone, as indicated by the lower tumor volume, tumor weight, and fewer Ki67 positive cells following the combined treatment (Figure6A–C and Figure S6A, Supporting Information). The gene discussed is MKI67; the disease is neoplasm.