In contrast, the tumor suppressor function of KMT5C is found in the breast cancer and colon cancer.[17, 19] However, a recent study reports that KMT5C loss only promotes right‐sided colon cancer progression, but has no effect in left‐sided colon cancer.[18] Thus, KMT5C exhibits tissue‐specific functions in human cancers. This evidence concerns the gene KMT5C and malignant colon neoplasm.