Next, we further examined the tumor immune microenvironment of the above tumor xenograft mouse model by flow cytometry assay and the results showed that the proportions of CD3+ T cells and CD8+ T cells were increased in the shKmt5c group, and the production of cytotoxic molecules IFN‐γ and GZMB were also upregulated in the tumor‐infiltrating CD8+ T cells of the shKmt5c group, but these improvements in the tumor immune microenvironment of the shKmt5c group could be almost abolished by Ccl5 knockdown (Figure 5G–I and Figure S5I, Supporting Information). Here, IFNG is linked to neoplasm.