Furthermore, IHC analysis also revealed that Kmt5c knockdown significantly enhanced the infiltration of CD3+ T and CD8+ T cells, and upregulated the expression level of IFN‐γ, but these improvements in the immune microenvironment of the shKmt5c group could be almost abolished by Ccl5 knockdown (Figure S5J,K, Supporting Information), suggesting that CCL5 is required for the role of KMT5C in regulating tumor immune microenvironment. Here, IFNG is linked to neoplasm.