DNA damage response (DDR) is the essential process for the perception and responses to DNA damage, which collectively encompasses DNA repair, cell cycle regulation, DNA replication, and apoptosis.[9] In addition, DNA repair defects in cancer cells elevate the damaged cytosolic DNA, resulting in the activation of cyclin GMP‐AMP synthase/stimulator of IFN genes (cGAS‐STING) signaling and conferring a more sensitive phenotype to immunotherapy.[10, 11] Thus, targeting epigenetic regulators may be a promising strategy to enhance the efficacy of immunotherapy in cancer. This evidence concerns the gene CGAS and cancer.