Chronic helminthic infection suppresses both Th1 and Th2 responses by actively inducing the expansion of forkhead box protein 3 (FOXP3+) regulatory T cells, IL-10-producing B cells, and alternatively activated macrophages (AAMs), which together promote the release of regulatory cytokines such as TGF-β and IL-10 [50]. The gene discussed is IL10; the disease is helminthiasis.