GPRIN2 and Down syndrome: On the other hand, the deletion of GPRIN2 (G-Protein-Regulated Inducer Of Neurite Outgrowth 2) could be involved in our patient’s phenotype, as it has been reported as a candidate modifier gene in different syndromes, including 16p11.2-p12.2 duplication syndrome (a genomic condition differentiated from euchromatic variations in 16p11.2), which is associated with defects in digit formation [8,9].