The complex ECM remodeling processes may influence immune cell infiltration.[52] TAMs can produce collagen and obstruct antitumor immunity not only by physically excluding CD8+ T cells, but also by inducing a mechano‐metabolic reprogramming of TAMs, resulting in an unfavorable metabolic landscape for CD8+ T cells.[24] Based on ovarian cancer scRNA‐seq, we also observed that the ratio of M1/M2 macrophages is lower in patients with high Matrix index than in those with low Matrix index (Figure 6I). Here, CD8A is linked to ovarian cancer.