Therefore, we further screened for potential natural compounds targeting COL1A1 and identified halofuginone (HF), a clinically active derivative of febrifugine using Encyclopedia of Traditional Chinese Medicine (ETCM).[25] HF is a specific inhibitor of collagen type I (Col1) synthesis and attenuates osteoarthritis (OA) by inhibition of TGFβ activity.[26, 27] Therefore, we selected HF as a compound of targeting COL1A1. This evidence concerns the gene TGFB1 and hydrops fetalis.