Wang et al.[5] demonstrated that in vitro knockdown of the orphan receptor GPRC5C in human aortic VSMCs reduced angiotensin II (Ang II)‐induced inositol phosphate production and myosin light chain phosphorylation, thereby decreasing Ang II binding to AT1 receptors and alleviating established arterial hypertension. This evidence concerns the gene AGT and Hypertension.