LDH‐A bound to HIF‐1α and enhanced its stability by obstructing proteasome degradation, leading to increased transactivation of glycolytic genes.[30] These findings, together with the heterogeneity of different cancer types, might account for the difference that colon cancer cells were more sensitive to TZP than the other types of cancer cells. Here, HIF1A is linked to malignant colon neoplasm.