The GLP‐1R agonist exendin‐4 (Ex‐4) induced mouse colon cancer CT‐26 cell apoptosis in vitro, augmented apoptosis induced by irinotecan, and increased tumor apoptosis in the mouse model.[9] And it also induced endometrial cancer Ishikawa cell apoptosis.[34] Increased apoptosis by GLP‐1R agonist liraglutide was also seen in CRC cells.[35] In this study, TZP exerted inhibitory effects on proliferation in cancer cells (MC36, CT26, HCT116, and RKO), but did not affect the viability of mouse embryonic hepatocytes BNL CL.2 (Figures S1 and S2, Supporting Information). The gene discussed is GLP1R; the disease is neoplasm.