Treating CRC cells with chemical inhibitors of PFKFB3 (PFK‐158, 10 μM) and HIF‐1α (LW6, 50 μM) or lentivirus to specifically knockdown PFK‐1, the results indicated that inhibition of the expression or transcription of these three key molecules significantly suppressed CRC cell migration and proliferation (Figures S11 and S12, Supporting Information). Here, PFKM is linked to colorectal carcinoma.