Increased Fis1 expression is associated with decreased Mff expression,[52] while Fis1 knockdown results in Mff upregulation.[53] Notably, targeted inhibition of the Drp1‐Fis1 pathway has demonstrated significant anti‐tumor effects, whereas Drp1‐Mff inhibition has been linked to pro‐tumor activity.[54] These observations suggest that fission‐dependent mitochondrial regulation in diabetes directly influences mitochondrial homeostasis and macrophage‐mediated mitochondrial transfer, which propagates regenerative signals. Here, FIS1 is linked to diabetes mellitus.