We examine the interaction between the brain with well‐known myokines, including brain‐derived neurotrophic factor, macrophage colony‐stimulating factor, vascular endothelial growth factor and cathepsin B. Neuroinflammation accumulates in the ageing brain and leads to cognitive decline, impaired motor skills and increased susceptibility to neurodegenerative diseases. Here, CTSB is linked to Mental deterioration.