Darja Andreev and colleagues have shown that EPX, another eosinophil protein, helps regulate osteoclast activity and slows osteoarthritis progression.[28] Based on those findings and our observations linking Di and EMBP, we hypothesize that eosinophils may also alleviate the progression of TMJOA through EMBP secretion, which requires further experimental validation in the future. Here, PRG2 is linked to osteoarthritis.