IL6 and rheumatoid arthritis: FFAs promote the release of key inflammatory mediators, including IL‐6, IL‐8, MCP‐1, and matrix‐degrading enzymes pro‐MMP‐1 and MMP‐3.[30] Conversely, polyunsaturated fatty acids like docosahexaenoic acid (DHA) inhibit RA inflammation by reducing TNF‐α and IL‐6 levels in the bloodstream.