To further explore the role of GDF10 in HSC activation and liver fibrosis, we generated HSC‐specific Gdf10 transgenic (Gdf10TG) mice by crossing Lrat‐Cre mice with the Gdf10 LoxP mice harboring the LoxP‐Stop‐LoxP‐Gdf10 cassette in the Rosa26 locus (Figure4A,B; Figure S6A,B, Supporting Information). Here, LRAT is linked to Hepatic fibrosis.