MAT2A and neoplasm: Besides, using the RNA‐seq data of colon adenocarcinoma (COAD) cohort from TCGA database, we found that the expression of MAT2A, a rate‐limiting enzyme that primarily catalyzes the synthesis of SAM,[36] was significantly higher in COAD tumor tissues than in adjacent normal tissues, and it was positively correlated with the expression of PCSK9 in tumor tissues (Figure3A,B).