Besides, using the RNA‐seq data of colon adenocarcinoma (COAD) cohort from TCGA database, we found that the expression of MAT2A, a rate‐limiting enzyme that primarily catalyzes the synthesis of SAM,[36] was significantly higher in COAD tumor tissues than in adjacent normal tissues, and it was positively correlated with the expression of PCSK9 in tumor tissues (Figure3A,B). Here, PCSK9 is linked to colon adenocarcinoma.