To establish a more linear relationship between apoptosis and the FcγRIIB/Fgl2 axis, transgenic mice that constitutively express Fgl2 received melanoma tumors and results demonstrated a significant reduction in the cell number (Figure 2D) and frequency (Figure 2E) of FcγRIIB+CD44hiCD8+ T cells in B16 tumor–bearing Fgl2-transgenic mice compared with WT mice. This evidence concerns the gene FCGR2B and melanoma.