TNFRSF6B and Sepsis: Proofs include the following: 1) the plasma DcR3 levels exhibited a significant disparity between survivors and non-survivors in patients with sepsis or septic shock; 2) the DcR3 levels were positively correlated with organ dysfunction as measured by the SOFA score; 3) among the four biomarkers, DcR3 was the only one independently associated with the 28-day mortality in both cohorts; and 4) the efficacy of DcR3 alone for outcome prediction was credible, which could be further improved when coupled with SOFA score.