To the sepsis subgroup, the AUCs (95% CIs) in descending order were 0.749 (0.669–0.817) for SOFA score, 0.731 (0.650–0.801) for DcR3, 0.658 (0.574–0.736) for PCT, 0.637 (0.552–0.715) for IL-6, and 0.617 (0.532–0.697) for CRP; to the septic shock subgroup, the AUCs (95% CIs) were 0.711 (0.596–0.808) for DcR3, 0.704 (0.590–0.803) for SOFA score, 0.609 (0.491–0.718) for PCT, 0.578 (0.460–0.689) for IL-6m and 0.552 (0.435–0.666) for CRP. The gene discussed is CRP; the disease is septic shock.