Viral clearance occurred earlier in lean mice compared to Lepr-deficient, T2DM mice, with viral titers of <10 PFU/mg detected in only 2/4 lean mice at 7 dpi, while infectious virus was detected in all Lepr-deficient, T2DM mice at this timepoint (average: 77 ± 31 PFU/mg). The gene discussed is LEPR; the disease is type 2 diabetes mellitus.