Histological changes and viral titers in the lungs of Lepr-deficient, T2DM mice were associated with significantly high levels of SARS-CoV-2 N antigen in bronchiolar epithelial cells and in rare alveolar epithelial cells (alveolar type 1 cells) at 2 dpi and with lower levels persisting through 7 dpi (Figures 2B, O–R). Here, LEPR is linked to type 2 diabetes mellitus.