Although a comparable SARS-CoV-2-S-specific CD8+ T lymphocyte response was detected at 14 dpi in both groups of mice (P ≤ 0.001; Figure 8H), it was short-lived in the lean mice compared to the Lepr-deficient, T2DM mice, in which it persisted until 21 dpi (P = 0.007; Figure 8I). This evidence concerns the gene LEPR and type 2 diabetes mellitus.