CD4 and type 2 diabetes mellitus: Conversely, when compared with the control peptides, we observed a significant increase in the percentage of CD4+ IFNγ+ in response to SARS-CoV-2 N-specific peptides starting at 10 dpi for both lean (P ≤ 0.001) and Lepr-deficient, T2DM (P = 0.003) mice (Figure 8C).