CD40LG and type 2 diabetes mellitus: While a SARS-CoV-2 N-specific IgM response was undetectable in both Lepr-deficient, T2DM, and lean mice (Figure 9B), there was a transient (short-lived) SARS-CoV-2 RBD-specific IgM response at 10 dpi (P ≤ 0.001) and 14 dpi (P = 0.05) only identified in Lepr-deficient, T2DM mice (Figure 9C).