LEPR and type 2 diabetes mellitus: Several DEGs were uniquely observed in the lung of lean mice at 4 dpi (1,933 DEGs) and Lepr-deficient, T2DM mice at 4 dpi (1,557 DEGs), while only 274 DEGs and 60 DEGs were uniquely observed for Lepr-deficient, T2DM mice at 2 dpi and lean mice at 2 dpi, respectively (Figure 4D).