GO biological process analysis was subsequently performed when taking into account the 282 DEGs uniquely identified in Lepr-deficient, T2DM mice at 2 and 4 dpi and results demonstrated an increase of biological processes related to interferon beta (IFNβ) responses, IFNγ, regulation of viral process and cytokine production (Figure 4E). The gene discussed is LEPR; the disease is type 2 diabetes mellitus.