ISG15 and type 2 diabetes mellitus: However, several genes involved in the type I interferon signaling pathway (Isg15, Stat1, Stat2, Ifit3, Irf7) and in the cytokine storm pathway (Il6, Ccl2, Ccl6 and Cxcl10) were present in the “Hub gene” sets of Lepr-deficient, T2DM mice at 2 dpi and 4 dpi (Figures 5A, B; Supplementary Figure S7).