Lepr-deficient, T2DM mice are obese (mean body weight of 41.50 ± 2.12 g) compared to their lean counterparts (mean body weight 27.85 ± 1.49 g) (P ≤ 0.001; Figure 1B) and hyperglycemic, with glycemia levels >3-fold higher than lean counterparts (P ≤ 0.001; Figure 1C). Here, LEPR is linked to type 2 diabetes mellitus.