Here, a significant reduction of both Ace2 (P = 0.008) and Tmprss2 (P = 0.047) mRNA expression was measured in the lung of Lepr-deficient, T2DM at 2 dpi, likely associated with bronchial epithelial turnover (Supplementary Figures S5A, S5B) as previously suggested (Thieulent et al., 2023). This evidence concerns the gene TMPRSS2 and type 2 diabetes mellitus.