GO biological process analysis was subsequently performed when taking into account the 282 DEGs uniquely identified in Lepr-deficient, T2DM mice at 2 and 4 dpi and results demonstrated an increase of biological processes related to interferon beta (IFNβ) responses, IFNγ, regulation of viral process and cytokine production (Figure 4E). Here, IFNG is linked to type 2 diabetes mellitus.