Among the IgG subclasses elicited against SARS-CoV-2 N, both groups of mice similarly elicited an N-specific IgG1, IgG2b and IgG2c response that correlated with the total N-specific IgG response (with a specific reduction of IgG subclass levels in lean mice compared to Lepr-deficient, T2DM mice at 21 dpi), while no N-specific IgG2a subclass response was induced (Figure 9D). This evidence concerns the gene LEPR and type 2 diabetes mellitus.