LEPR and type 2 diabetes mellitus: A total of 2,139 differentially expressed genes (DEGs) were identified between the lungs of Lepr-deficient, T2DM, and lean mice, including 767 up-regulated DEGs (log2 FC > 0.5) and 1,372 down-regulated DEGs (log2 FC < 0.5) in the lung of the former group (Figure 3B).