LEPR and type 2 diabetes mellitus: We determined that expression of Ifnb1 by RNAscope®in situ hybridization in the lung of SARS-CoV-2-infected Lepr-deficient, T2DM mice involved bronchiolar epithelial cells, with both intranuclear and intracytoplasmic signal detection (P = 0.001; Figures 7D, E).