In contrast, Lepr-deficient, T2DM mice exhibited mild multifocal necrotizing bronchiolitis extending up to 4 dpi, followed by only minimal multifocal interstitial pneumonia characterized by few peribronchiolar, perivascular and interstitial lymphocytes and macrophages that persisted through 14 dpi (Figures 2A, G–J, and Supplementary Figure S4). This evidence concerns the gene LEPR and type 2 diabetes mellitus.