APOL-1 and kidney disease is a life-altering disease which results in increased medical visits, treatments and therapies, and decreased quality of life resulting in an increase of fear, depression, anxiety, guilt, and a constant overwhelmed state.Disease status and comorbid diseases result in priorities that vary for individuals with high-risk APOL-1 alleles.Physical complications associated with dialysis or kidney transplantation, adverse reactions to therapies, and treatment complications. The gene discussed is APOL1; the disease is major depressive disorder.