Experiments with oxygen and glucose deprivation (OGD), as in vitro stroke model, revealed activation of neuroprotection when RBM3 was overexpressed, attenuating apoptosis in PC12 cells (Si et al., 2020), in N2a cells (Zhang et al., 2023), and even in organotypic brain slice culture (OBSC); in the last case by stimulating anti-inflammatory microglia proliferation (Zhao et al., 2024). This evidence concerns the gene RBM3 and stroke disorder.