NFKB1 and Cognitive impairment: In parallel, it has been proven that targeting neuroinflammation via suppressing several signaling encompassing NF-κB, NLR Family Pyrin Domain Containing 3 (NLRP3), and PI3K/protein kinase B (Akt), and their downstream pro-inflammatory cytokines rescues cognitive deficit associated with neurodegenerative disorders such as Alzheimer’s disease (Dempsey et al., 2017; Tyler and Tyler, 2023).