ACHE and metabolic disease: Homeostasis in neurotransmitters can be affected by neurotransmitter loss, changes in redox state, oxidative insult, inflammation, metabolic disorders, alterations in synaptic protein concentrations, Ca2+ imbalance, and neuronal degeneration (Pradeepkiran and Reddy, 2020) This research showed that DOX-treated rats exhibited elevated levels of AChE and reduced ACh levels in the hippocampus.