CD8A and neoplasm: In immature TLS (iTLS), besides T, B cells and FDCs, there often are aggregates of immune suppressive cells that suppress anti-tumor immunity such as higher programmed death-ligand 1 tumor-associated Macs (26), immature DCs (26), regulatory T cells (26, 27), PD-1high CD8 T cells (26, 28) and PD-1highCD4 T cells (28).