Conversely, in certain cancer types, including diffuse large B-cell lymphoma (DLBC), kidney chromophobe (KICH), kidney renal papillary cell carcinoma (KIRP), thyroid carcinoma (THCA), and thymoma (THYM), We observed that the expression of HKDC1 exhibits a positive correlation with methylation levels. The gene discussed is HKDC1; the disease is diffuse large B-cell lymphoma.