Conversely, in certain cancer types, including diffuse large B-cell lymphoma (DLBC), kidney chromophobe (KICH), kidney renal papillary cell carcinoma (KIRP), thyroid carcinoma (THCA), and thymoma (THYM), We observed that the expression of HKDC1 exhibits a positive correlation with methylation levels. This evidence concerns the gene HKDC1 and thyroid gland carcinoma.