Interestingly, we found a cluster of CD45+ cells co-expressing high levels of PD1, TIM3, and PTK7, the latter is a pseudokinase overexpressed in HCC,24,45 which was decreased in MEKi+BCL-XLi treated tumors compared with untreated or Decitabine-treated tumors (Figures 8E and 8F). The gene discussed is PDCD1; the disease is hepatocellular carcinoma.