Several of the DEPs have been reported previously in relation to COVID-19 severity, including S100 calcium binding protein A8/A9 (S100A8/9), serum amyloid A1/A2 (SAA1/2), CRP, cystatin C (CST3), angiotensinogen (AGT), and ITIH2.36 The gene discussed is CST3; the disease is COVID-19.