In the liver, an increase in the expression of positive-APPs, a decrease in the expression of albumin and an upregulation of autophagy occurred at the pre-Cx phase, while at the onset of cachexia, rpS6 phosphorylation and eIF2α signaling were strongly activated in this organ, along with increased expression of ATF4-target genes involved in amino acid synthesis and transport, as well as autophagy. The gene discussed is ATF4; the disease is Cachexia.