We first observed that (S240/244)-rpS6 phosphorylation was unaffected at the pre-Cx stage, but strongly increased in livers of Cx mice compared to sham-injected- and pre-Cx mice (Figure 6A), suggesting an increase in mTORC1/S6K1-mediated hepatic protein synthesis at the onset of cachexia. Here, RPS6 is linked to Cachexia.