NFKB1 and systemic lupus erythematosus: Li et al. (15) found that DHA effectively alleviates lupus symptoms in BXSB mice, a well-established animal model for systemic lupus erythematosus (SLE), by suppressing the production of tumor necrosis factor α (TNF-α) and impeding the translocation of NF-κB within its signaling pathway.