Heightened levels of CXCL8 along with overexpression of CXCR1 or CXCR2 have been implicated in promoting tumor cell proliferation and metastasis through the activation of PI3K/AKT and ERK1/2 MAPK signaling pathways (8, 13, 15, 16). The gene discussed is CXCR1; the disease is neoplasm.