DEGs were primarily associated with “cellular divalent inorganic cation homeostasis,” “leukocyte cell-cell adhesion,” “leukocyte migration,” “skeletal muscle organ development,” and “skeletal muscle tissue development” in GO entries (Figures 5A, B) and were mainly enriched in “African trypanosomiasis,” “apelin signaling pathway,” “cell adhesion molecules,” “fluid shear stress and atherosclerosis,” “malaria” and other KEGG pathways (Figures 5C, D). The gene discussed is APLN; the disease is human African trypanosomiasis.