Newly published research (61) has revealed that depletion of nutrient-dependent lysosomal signaling nodes activates the transcription factor EB (Tfeb), and deficiency in Follicular Lymphoma Overexpressed Gene (Flcn) enhances protective responses in intestinal TRM cells, with the Flcn-Tfeb axis mechanistically inhibiting retinoic acid-induced CCR9 expression to promote TGF-β-mediated lineage differentiation programs. This evidence concerns the gene TFEB and lymphoma.