CD8A and cancer: Specifically, within the high TMED9 group, cancer cell antigen release (step 1), immune cell trafficking (step 4)—which includes recruitment of CD8 T cells, Th1 cells, Th22 cells, monocytes, natural killer (NK) cells, eosinophils, basophils, Th2 cells, and regulatory T cells (Treg)—and T cell recognition of cancer cells (step 6) were upregulated, while priming and activation (step 3) and cancer cell killing (step 7) were downregulated, as shown in Figure 8B.