Clinical studies have shown that CD47, as a natural immune checkpoint molecule, is highly expressed in cancer tissues such as gastric cancer, leukemia stem cells, Hodgkin’s lymphoma, breast cancer, cervical cancer, pancreatic cancer, and non-small cell lung cancer, and even the level of CD47 expression in tumor stem cells is higher than that in tumor cells (40–46). This evidence concerns the gene CD47 and leukemia.