(94) used mass spectrometry to analyze COMP degradation fragments in OA cartilage, and found that COMP degradation exposed some neoantigenic epitopes that some full-length proteins do not possess, and in the future, if we can comprehensively analyze the neoantigenic epitopes of COMP degradation fragments in arthritis, it will be helpful in the application and development of COMP as a molecular marker for arthritis. Here, COMP is linked to Arthritis.