In addition, clinical studies have shown a significant correlation between serum aggrecan levels and the occurrence of lumbar disc herniation (78), with patients with lumbar disc herniation having significantly lower serum aggrecan levels than the healthy population, and this study even found that serum aggrecan also differed significantly among patients with different clinical efficacy, with treatment-naïve lumbar disc herniation patients having serum aggrecan levels were even lower (79). This evidence concerns the gene ACAN and lumbar disc herniation.