The ubiquitously expressed IKK complex links these transcription factors to immune receptors, including T-cell and B-cell receptors, Toll-like receptors, and inflammatory cytokine (TNF- and interleukin [IL]-1ß) receptors (4) and certain variants in the IKBKB have been linked to increased susceptibility to autoimmunity and autoinflammation (5, 6). Here, IKBKB is linked to Autoimmunity.