This analysis enables the identification of key genes involved in immune and vascular pathways, revealing that the synergy between HERVs, microRNAs (miRNAs), and non-LTR retroviruses promotes a complex regulatory network that modulates critical genes such as CXCR1 and IL18RAP. These findings enhance our understanding of the molecular basis of severe dengue, emphasizing the intricate interplay of host genetic regulation in disease severity Supplementary Figure S1. The gene discussed is IL18RAP; the disease is dengue disease.