EGFR and neoplasm: PEGylated liposomal Dox (Caelyx) targeted to EGFR (αEGFR-Caelyx) was found to accumulate and penetrate the inner region of tumor spheroids with tumor-bearing mice intravenously treated with αEGFR-Caelyx, showing significantly decreased expansion of the tumor (Fig. 4B) [199].