Specifically, immunogenic PDT enhanced NK cell-membrane immunotherapy, which significantly promoted the infiltration of effector T cells (CD4+ and CD8+ T cells) in tumors for incredibly efficient tumor and abscopal tumor suppression [141].The anti-angiogenic therapies can normalize tumor vasculature, improving perfusion and reducing hypoxia to modulate the immunosuppressive TME [142]. Here, CD4 is linked to neoplasm.