MAOB and Alzheimer disease: Dual inhibitory activity against bothChE and MAO enzymes is apotential treatment strategy for AD; however, the difference in thebinding pockets of both target proteins makes this a challenging task.25 The weak inhibitory activity and binding affinityof substituted phthalimide for ChEs and MAO-B enzymes can potentiallybe improved with SAR studies, and therefore, we have devised a planto synthesize N-benzyl-substituted phthalimides bearingelectron-donating, electron-withdrawing, heterocyclic, and fluorinatedmoieties.