Invitro evaluation of synthesized compounds against cholinesterases(AChE/BChE) and monoamine oxidases (MAO-A/MAO-B) revealed that compound 3e had good potency against AChE (IC50 = 0.24 μM)and BChE (IC50 = 6.29 μM), while compound 3f had the highest inhibition of MAO-B (IC50 = 0.09 μM).Selected compounds (3e,f) showed no cytotoxicity againstthe neuroblastoma cell line (SH-SY5Y) and normal human embryonic HEK-293cells. This evidence concerns the gene ACHE and neuroblastoma.