ACHE and Alzheimer disease: ChEs includeacetylcholinesterase (AChE) and butyrylcholinesterase (BChE), synthesizedby neurons residing in the brainstem and basal forebrain with axonalprojections throughout the brain.5 TheseChEs and Aβ plaque depositions are also interrelated, as reflectedin AD patients.6 The inhibition of AChEand BChE serves as a potential target for treatment and delaying theprogression of a group of neurological diseases, including AD.7