The univariate Cox regression analysis indicated that in the DKD+NDKD group, serum creatinine, 24-hour urinary protein quantification, eGFR, serum albumin, urea nitrogen,ACR, NAG, cystatin C, and massive proteinuria (>3.5 g/day) were associated with adverse renal outcomes. The gene discussed is ALB; the disease is diabetic kidney disease.