BDNF and columnar cell hyperplasia of the breast: It achieves these effects by reducing the activation of microglia and lipopolysaccharides [22, 23], acting as a HDAC inhibitor [24], increasing the level of brain-derived neurotrophic factor (BDNF) [25], promoting epigenetic modifications in the central nervous system (CNS) [22], causing neuroendocrine alterations [22], and having protective effects against chronic cerebral hypoperfusion (CCH) and neuroinflammation [26].