The relationship between AD and LDs in the brain was first identified in 1907 when LDs were noted as adipose saccules in glial cells alongside extracellular plaques formed by beta‐amyloid (Aβ) and neurofibrillary tangles formed by phosphorylated‐tau (p‐tau) in neurons [14]. The gene discussed is MAPT; the disease is Alzheimer disease.