BDNF and Huntington disease: Similarly, in Emx1-Cre/Q140 or Emx1-Cre/Q175 heterozygous mouse models, the partial-fusion and full-fusion modes of BDNF-containing vesicles were significantly changed after the onset of HD symptoms, suggesting that abnormal BDNF transcription, transport, and cortical axonal secretion in the striatum contribute to the development of HD [61].