A complementary property of α‐acyloxy carboxamide 23 is represented by its channel selectivity, as evidenced by its preferential action on TRPM8 channels, and lower interaction with structurally related thermosensory channels such as TRPV1 and TRPA1, which are also highly expressed in nociceptive neurons and contribute to the etiology of peripheral neuropathies. This evidence concerns the gene TRPV1 and peripheral neuropathy.