The analyses identified robust causal relationships between BD and the proteins inter‐alpha‐trypsin inhibitor heavy chain (ITIH)5 (OR = 1.08, 95% CI = 1.00–1.17, p = 0.04) and neurofascin (NFASC) (OR = 0.96, 95% CI = 0.92–1.00, p = 0.042). The gene discussed is ITIH5; the disease is Behcet disease.