However, for patients with tumor response in the irAE group, the median onset time of irAE and median TTR were 4.7 (range, 0.4–26.7) months and 1.9 (range, 1.6–5.6) months, respectively, with the onset of irAEs occurring later than the time of PR or CR in 75.0% (30/40) of patients (Figure 2). The gene discussed is TTR; the disease is neoplasm.