A sedentary lifestyle and lack of physical activity contribute to dyslipidemia, obesity, and overweight, increasing the risk of cardiovascular diseases through factors such as high waist‐to‐hip ratio, lipid disorders, inappropriate lipid concentrations, and imbalanced apolipoprotein levels A, apolipoprotein B, and Apo‐B/Apo‐A ratio, which are major factors associated with cardiovascular diseases (Delfan et al. 2024; Ghorbanian et al. 2015; Hosseinian et al. 2016). Here, APOB is linked to obesity due to melanocortin 4 receptor deficiency.