The study observed that interventions such as 12 weeks of high‐intensity interval training (HIIT), spirulina supplementation, and a combination of HIIT with spirulina supplementation resulted in an increase in apolipoprotein‐AI (Apo‐AI) levels and a decrease in apolipoprotein‐B (Apo‐B) and apolipoprotein‐J (Apo‐J) levels in men with obesity compared to the control group. This evidence concerns the gene CLU and obesity due to melanocortin 4 receptor deficiency.