Given the lack of existing research on the effects of HIIT and spirulina supplementation on apolipoproteins (Apo‐A, Apo‐B, and Apo‐J) in men with obesity, this study aimed to investigate the potential impact of a 12‐week HIIT and spirulina supplementation regimen on these parameters, as well as insulin resistance and body composition in this specific population. The gene discussed is APOA1; the disease is Insulin resistance.