Vitamin B6 deficiency has previously been studied in flies carrying mutations in genes involved in PLP biosynthesis, such as Pdxk and Sgll/PNPO, and resulted in genome instability, diabetes, impaired lipid metabolism and altered nucleotide pool, consistently with the role of PLP as an antioxidant, as well as with role of this coenzyme implicated in a plethora of metabolic activities (Marzio et al., 2014; Mascolo et al., 2020). The gene discussed is PNPO; the disease is diabetes mellitus.