A study on the Pfizer-BioNTech SARS-COV2 mRNA vaccine has highlighted the role of cDC1 in T-cell induction.42 Similarly, our research underscores the critical role of cDC1 in mediating the anti-tumor effects of RNA vaccines, demonstrating diminished CD8 T cell responses in cDC1-deficient mice. This evidence concerns the gene MPPE1 and neoplasm.